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- In 639, a plague broke out, originating in Nicopolis, or Imwas, in the modern state of Israel.
- The city no longer exists as it was destroyed by Israeli army during Six Day war.
- It is estimated around 20000 people died from this plague. Among them were many prominent Sahabas.
- The most well-knonw of all was Abu Ubaidah, the general that succeeded KIW in Syria
- Another companion was Muadh ibn Jabal – most famous for these instructions he received from Prophet Muhammad before embarking to Syria